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How does Zofran work so fast? Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting. The standard tablets that are swallowed will start to work within half an hour to 2 hours. The orally disintegrating tablets or oral soluble films are absorbed very quickly into the blood stream so start to work rapidly.
Is Zofran available over the counter? One cannot simply buy ondansetron as it is a prescription medication. Because of this, ondansetron is also not available over-the-counter (OTC) at pharmacies. However, Push Health connects people who require an ondansetron ODT prescription with providers who can prescribe the medication if it is appropriate.
How often can I take Zofran for nausea? For those ages 4 to 11, patients should take a 4-mg tablet or rapidly disintegrating tablet or 5 mL of liquid three times per day. Zofran can be taken with or without food, and patients can continue their normal diet while taking Zofran.
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