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Is diclofenac COX 2 selective? As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase -1 (COX -1) and cyclooxygenase - 2 (COX - 2) with relative equipotency.
Does diclofenac make you retain water? Water retention warning: This drug can cause your body to retain water, leading to edema (swelling or puffiness). Liver function warning: Using diclofenac may affect some of your liver function tests. Your doctor should monitor your liver function while you use diclofenac.
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